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KMID : 0861120180220020077
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Korean Journal of Oriental Preventive Medicine
2018 Volume.22 No. 2 p.77 ~ p.107
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Anti-obese related pharmacological effects of standard potato protein extracts on the 45%Kcal high fat diet supplied mice
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Kang Su-Jin
Song Chang-Hyun
Kim Jong-Kyu
Chun Yoon-Seok
Han Chang-Hyun
Lee Young-Joon
Ku Sae-Kwang
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Abstract
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Objectives : In present study, therefore, possible beneficial pharmacological activities of standard potato protein extracts (SPE) were observed on the mild diabetic obese mice.
Methods : After end of 12 weeks of continuous oral administrations of three different dosages of SPE 400, 200 and 100 mg/kg, or metformin 250 mg/kg, analyzed the hepatoprotective, hypolipidemic, hypoglycemic, nephroprotective and anti-obesity effects, separately. In addition, liver antioxidant defense systems were additionally measured with lipid metabolism-related genes expressions and hepatic glucose-regulating enzyme activities for action mechanism.
Results : All of diabetes and related complications including obesity were significantly inhibited by treatment of SPE 400, 200 and 100 mg/kg, dose-dependently, and they also dramatically normalized the hepatic lipid peroxidation and depletion of liver endogenous antioxidant defense system, the changes of the hepatic glucose-regulating enzyme activities, also changes of the lipid metabolism-related genes expressions including hepatic AMPKα1 and AMPKα2 mRNA expressions, dose-dependently. Especially, SPE 200 mg/kg constantly showed favorable inhibitory activities against type II diabetes and related complications as comparable to those of metformin 250 mg/kg in HFD mice, respectively.
Conclusions : The present work demonstrated that SPE 400, 200 and 100 mg/kg showed favorable anti-diabetic and related complications including obesity refinement activities in HFD mice, through AMPK upregulation mediated hepatic glucose enzyme activity and lipid metabolism-related genes expression, antioxidant defense system and pancreatic lipid digestion enzyme modulatory activities.
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KEYWORD
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Standard Potato Protein Extracts, 45%Kcal high fat diet, mouse, obese, diabetes
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